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Intestinal Glucose Absorption Is Lower in Obese than in Lean Zucker Rats¹

Departament de Bioquímica i Fisiologia, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08071-Barcelona, Spain

Obese Zucker (fa/fa) rats had lower intestinal glucose absorption following an intragastric [U-¹⁴C]glucose load than lean (+/?) Zucker rats. In the fa/fa animals, the rate of oxidation of the tracer to ¹⁴CO₂ was similar to that observed in their lean counterparts. Although there were no differences in the incorporation of the tracer in liver and skeletal muscle glycogen, the conversion and incorporation of [U-¹⁴C]glucose into tissue [¹⁴C]lipid was higher in the obese animals. Isolated enterocytes from lean and obese Zucker rats showed a similar capacity for [U-¹⁴C]glucose utilization. Reconstituted brush border membrane vesicles from obese Zucker rats showed a higher V_max for glucose transport than those from their lean counterparts. The lower glucose absorption found in the fa/fa rats in vivo may contribute to the maintenance of normoglycemia in these animals.

KEY WORDS: • Zucker rats • glucose transport • intestinal absorption • obesity

¹ Supported in part by a grant (PB86/0512) from the "Dirección General de Investigación Científica y Técnica" of the Spanish Ministry of Education.

² To whom correspondence should be addressed.

Manuscript received 9 July 1992. Revision accepted 7 January 1993.