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Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada N2L 3G6
Responses of vitamin E-depleted female rats to acute exercise and chronic exercise training were tested. Rats were fed either a control diet (+E rats) or a vitamin E-depleted diet (-E rats). After 8 wk, subgroups of the +E and -E rats performed treadmill exercise for 45 min at 28 m/min, 15% grade, and were immediately killed. Vitamin E concentrations were 80–90% lower in liver, heart and muscles in -E rats as determined by HPLC. There was no difference between +E and -E rats in blood lactate concentration, creatine kinase, lipid peroxidation indices, hematocrit or hemoglobin concentration following acute exercise. Remaining rats were either trained for a further 8 wk at 40 m/min, 15% incline for up to 60 min/d or served as untrained controls. No differences in training tolerance were seen between diet groups, with 64% of +E rats and 71% of -E rats consistently completing 60 min of daily training. The training induced similar adaptive elevations in succinate dehydrogenase activity (31–107%) in various hind limb muscles of both +E and -E rats. Trained +E rats had lower vitamin E concentrations in some but not all tissues when compared with untrained +E controls. These results suggest that consumption of a vitamin E-free diet for 8 wk did not result in differences in blood indices associated with exercise stress or in the ability to perform a submaximal acute exercise test when compared with controls. Additionally, rats fed the vitamin E-free diet for 16 wk and rats fed the control diet for 16 wk did not differ in their ability to complete and adapt to a vigorous endurance running program.
KEY WORDS: • vitamin E • rats • exercise training • peroxidation • succinate dehydrogenase
1 Presented in part at the American College of Sports Medicine Conference, May 1991, Orlando, FL [Houston, M., Tiidus, P. M., Behrens, W., Madere, R., Rosebush, D. & Kim, J. (1991) Effects of vitamin E deprivation on training ability of rats. Med. Sci. Sports Exercise 23: S78 (abs.)].
2 Supported by a grant from Natural Sciences and Engineering Research Council, Canada to M. E. Houston.
3 The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.
4 To whom reprint requests should be addressed, at the current address: Department of Physical Education, Wilfrid Laurier University, Waterloo ON Canada, N2L 3C5.
5 To whom correspondence should be addressed.
Manuscript received 5 November 1992. Revision accepted 19 January 1993.
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