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Use of the Colostrum-Deprived Piglet to Evaluate Parenteral Feeding Formulas¹

Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611-0370

Several different neonatal and infant piglet models have been invaluable as animal models in nutrition research. A preterm colostrum-deprived piglet model has been developed that is delivered at the desired gestational age, is cared for using the standard of care provided preterm human neonates including procedures for nutritional support and can be studied during pathological conditions induced under controlled conditions. The absolute values for each nutrient requirement would not be expected to be identical for preterm piglets and preterm human neonates. However, the effect of different levels of gestational maturity and superimposed pathophysiologies on nutrient requirements should be similar in the piglet and human neonate.

KEY WORDS: • total parenteral nutrition • neonate • piglet

¹ Presented as part of a symposium: Animal Models in Neonatal and Infant Nutrition Research, given at the 76th Annual Meeting of the Federation of American Societies for Experimental Biology, Anaheim, CA, April 8, 1992. This conference was sponsored by the American Institute of Nutrition. Guest editors for the symposium were Peggy R. Borum, Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL 32611, and Mulchand S. Patel, Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106.

² To whom correspondence should be addressed: Food Science and Human Nutrition Department, University of Florida, P. O. Box 110370, Gainesville, FL 32611-0370.