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Vitamin B-6 Status Indices Are Lower in Pregnant than in Nonpregnant Women but Urinary Excretion of 4-Pyridoxic Acid Does Not Differ^1,2,3,4,

Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907

The cause of reduced plasma pyridoxal-5'-phosphate (PLP) concentration and the validity of plasma PLP concentration as a vitamin B-6 status indicator during pregnancy are not well understood. In this study, pregnant and nonpregnant women consumed a controlled diet for 5 d to exclude dietary intake as a factor in altered vitamin B-6 metabolic utilization. Plasma PLP and pyridoxal (PL) concentrations were significantly lower and higher, respectively, and plasma PL+PLP concentration was significantly lower during pregnancy. When plasma PLP and PL concentrations were normalized based on plasma albumin concentration, the differences were less marked but were still significant. The erythrocyte aspartate aminotransferase activity coefficient was significantly greater in pregnant women which is a further indication of reduced vitamin B-6 concentrations in the blood. No difference was observed in the urinary excretion of 4-pyridoxic acid between the pregnant and nonpregnant women. Results of this study demonstrate that vitamin B-6 status indices are lower during pregnancy without differences in the urinary excretion of 4-pyridoxic acid.

KEY WORDS: • vitamin B-6 • pregnancy • rats • bioavailability

¹ A preliminary report was presented at Experimental Biology 93, March 28–April 1, 1993, New Orleans, LA [Wang, J. W. & Trumbo, P. R. (1993) Vitamin B-6 status and metabolism during pregnancy. FASEB J. 7: A744 (abs. 4295)].

² Supported in part by USDA CSRS NRICGP 91-37200-6274.

³ Journal paper no. 13781 of the Agricultural Experiment Station, Purdue University, West Lafayette, IN 47907.

⁴ The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore by hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.

⁵ To whom correspondence should be addressed.

Manuscript received 23 April 1993. Initial review completed 2 June 1993. Revision accepted 19 August 1993.

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