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United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202-9034
Because of nutritional and technical problems the AIN-76A rodent diet was revised. One of the new formulations was designated AIN-93G and was suggested for use during growth, pregnancy and lactation studies. Some major differences in this new formulation compared with the AIN-76A diet are as follows: 7 g soybean oil was substituted for 5 g corn oil/100 g diet to increase the amount of linolenic acid; the amounts of vitamins E and K were increased; cornstarch was substituted for most of the sucrose; the amount of phosphorus was reduced to eliminate the problem of nephrocalcinosis in female rats; L-cystine was substituted for DL-methionine; and the manganese concentration was reduced. Various developmental modifications of the AIN-93G diet were fed to weanling rats and mice to determine effects on growth and tissue mineralization. After rats were fed the developmental version of AIN-93G for 16 wk, body weights in both male and female rats were not different from those of rats fed a cereal-based nonpurified diet. After 13 wk, male mice fed this diet weighed 13% more than those fed the nonpurified diet. Body weights of female mice were not affected. The new diet formulation prevented kidney calcification in female rats and mice during 16 wk of feeding.
KEY WORDS: • growth • L-cystine • 17ß-estradiol • nephrocalcinosis • rats • mice
1 A portion of this work was presented at the Annual Meeting of the Federation of American Societies for Experimental Biology, April 5–9, 1992, Anaheim, CA [Reeves, P. G. (1992) Reformulation of the AIN-76 mineral mix to prevent kidney calcification in female rats. FASEB J. 6: A1651 (abs. 4138)].
2 The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.
3 Current address: Sanofi Diagnostics Pasteur, Chaska, MN.
Manuscript received 2 April 1993. Revision accepted 29 July 1993.
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