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Porcine Somatotropin Affects the Dietary Lysine Requirement and Net Lysine Utilization for Growing Pigs^{1, 2, 3,}

Department of Animal Science, Cornell University, Ithaca, NY 14853

This study was conducted to determine the effects of exogenous porcine somatotropin (pST) on the dietary lysine requirement and efficiency of absorbed lysine utilization for pigs during the 20- to 60-kg phase of growth. Seventy-two crossbred pigs (20 ± 0.7 kg body wt) received daily intramuscular injections of either excipient (0 dose) or pST (150 µg/kg body wt) and were fed diets in which protein and lysine concentrations ranged from 6.4 to 23.5 g/100 g diet and from 0.40 to 1.48 g/100 g diet, respectively. Nutrient density was altered to compensate for reduced feed intake with pST, but diets were approximately isocaloric. Rate and efficiency of gain and whole-body protein accretion rate exhibited a dose-response improvement (P < 0.01) to increases in dietary protein for both excipient and pST-treated pigs. Pigs receiving pST grew more rapidly and more efficiently than control counterparts (P < 0.01). Treatment with pST improved the rate of protein accretion (P < 0.01) at all but the lowest level of dietary protein. The net lysine utilization for lysine accretion and maintenance was 0.46 for control pigs and 0.57 for pigs receiving pST, a 24% improvement in the efficiency. Thus, treatment with pST increased the maximum rate of protein accretion as well as the partial efficiency with which dietary lysine is used for protein accretion. Consequently, only a 9% increase in dietary lysine was required to maximize protein deposition in pST-treated pigs, because the metabolic efficiency of lysine utilization was improved.

KEY WORDS: • swine • somatotropin • growth • protein deposition • lysine requirement

¹ Portions of this paper were presented at the 82nd annual meeting of the American Society of Animal Science, August 1990, Iowa State University, Ames, IA [Krick, B. J., Roneker, K. R., Harrell, R. J., Boyd, R. D., Beermann, D. H. & Kuntz, H. T. (1990) Impact of porcine somatotropin on the lysine requirement of growing pigs from 20 to 60 kg live weight. J. Anim. Sci. 68 (suppl. 1): 383 (abs.)].

² Research supported by the Cornell Agricultural Research Station, Pitman-Moore Inc., BioKyowa Inc. and Canada Packers Inc.

³ The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.

⁴ Current affiliation: Novus Europe s.a., Brussels, Belgium.

⁵ To whom correspondence and reprint requests should be addressed (252 Morrison Hall).

⁶ Current affiliation: Indiana Packers Co., Delphi, IN.

Manuscript received 14 January 1993. Revision accepted 1 July 1993.

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