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Pyridoxine-5'-ß-D-Glucoside: Metabolic Utilization in Rats during Pregnancy and Availability to the Fetus^{1, 2, 3, 4,}

Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907

Pyridoxine-5'-ß-D-glucoside (PNG), which is abundant in various plant-derived food products, has been shown to be poorly utilized in male rats and adult men. To assess the metabolic utilization of PNG during pregnancy and the availability to the fetus, [³H]PNG and [¹⁴C]pyridoxine (PN) were orally administered to 15-d pregnant rats for direct assessment of the intestinal absorption, tissue distribution, and urinary excretion of the radioisotopes. The level of ³H was significantly greater in the liver, and urinary excretion of ³H tended to be lower than that of ¹⁴C. The relative distribution of ³H among the groups of B-6 vitamers within the liver was similar to that for ¹⁴C. There was greater uptake by the fetus of ³H than of ¹⁴C. There was no difference in the relative concentrations of ³H and ¹⁴C among the groups of B-6 vitamers within the fetus. Results of this study suggest that the metabolic utilization of PNG is similar to that of PN during pregnancy. Therefore, the availability of vitamin B-6 derived from maternal PNG seems to be similar to that of vitamin B-6 derived from maternal PN.

KEY WORDS: • pregnancy • pyridoxine-ß-glucoside • bioavailability • vitamin B-6 • rats

¹ A preliminary report was presented at Experimental Biology 93, March 28–April 1, 1993, New Orleans, LA [Cheng, S. & Trumbo, P. R. (1993) The bioavailability of pyridoxine-ß-glucoside during pregnancy. FASEB J. 7: A744 (abs. 4295)].

² Supported in part by USDA CSRS NRICGP 91-37200-6274.

³ Journal paper no. 13813 of the Agricultural Experiment Station, Purdue University, West Lafayette, IN 47907.

⁴ The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.

⁵ To whom correspondence should be addressed.

Manuscript received 24 May 1993. Revision accepted 12 July 1993.