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Corandomization of Fats Improves Absorption in Rats^{1, 2,}

Wyeth-Ayerst Laboratories, Nutritional Research Department, Philadelphia, PA 19101

Human milk fat is well absorbed despite its large concentration of long-chain saturated fatty acids (LCSFA), particularly palmitic acid. The superior absorption has been ascribed in part to the uncommonly high proportion of the palmitic acid in the sn-2 position of the triglycerides, 70% in human milk triglycerides compared with 10–15% in the fats and oils commonly used in infant formula blends. Colipase-dependent pancreatic lipase selectively hydrolyzes the fatty acids at the sn-1 and 3 positions, yielding free fatty acids and the 2-monoglyceride, which are absorbable. Free palmitic acid, but not monopalmitin, can be lost as calcium soaps in the feces. The present study demonstrated that mixtures of coconut oil and palm olein are better absorbed by rats if the proportion of LCSFA in the sn-2 position is increased by the process of chemical randomization, in which the fatty acids of the native oils are redistributed equally to all three positions in the rear-ranged triglycerides. The fecal excretion of total fatty acids, essentially LCSFA, from the mixtures in which the oils were randomized together (corandomized) was 30 to 60% less than from the mixtures of native oils.

KEY WORDS: • infant formula fat • absorption • corandomized oils • rats

¹ Presented in part at the Annual Meeting of the American Institute of Nutrition, April 1991, Anaheim, CA [Lien, E. L., Tomarelli, R. M. & Yuhas, R. J. (1991) Fat absorption of corandomized triglycerides in rats. FASEB J. 6: A1305 (abs.)].

² The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.

³ To whom correspondence should be addressed.

Manuscript received 27 January 1993. Revision accepted 1 July 1993.