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Coconut Oil and Sesame Oil Affect Lymphatic Absorption of Cholesterol and Fatty Acids in Rats^{1, 2,}

Subramaniam Satchithanandam³, Marla Reicks⁴, Richard J. Calvert, Marie M. Cassidy^* and David Kritchevsky

U.S. Food and Drug Administration, Division of Nutrition, Laurel, MD 20708 ^* Department of Physiology, George Washington University School of Medicine and Health Sciences, Washington, DC 20037 The Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104

Five groups of male Wistar rats weighing 200 g consumed 12 or 24% sesame oil or coconut oil diets or a control diet (14% corn oil) ad libitum for 4 wk. The thoracic ducts of these rats were cannulated, and a lipid emulsion containing [³H]cholesterol and [¹⁴C]oleic acid was given through a duodenal catheter. Lymph was collected for 24 h and the isotopic tracers for cholesterol and fatty acid were measured. Rats fed the 24% sesame oil diet had significantly lower lymphatic cholesterol and fatty acid compared with the control group. Absorption of oleic acid in rats fed 24% coconut oil was significantly greater than in controls during 0–8 h but was not significantly different during 0–24 h. There were no differences among groups in the distribution of cholesterol and oleic acid either in the lymph lipoproteins or in the lipid classes. The significant reduction in lymph cholesterol and fatty acids due to sesame oil feeding may be an important factor in reducing hypercholesterolemia.

KEY WORDS: • sesame oil • coconut oil • lymph • cholesterol • rats • fatty acids

¹ Presented in part at the 74th Annual Meeting of the Federation of American Societies for Experimental Biology, April 21–25, 1991, Atlanta, GA [Satchithanandam, S., Calvert, R. J., Reicks, M. R. & Chanderbhan, R. (1991) Effect of coconut oil and sesame oil on lymphatic absorption of cholesterol and fatty acids. FASEB J. 5: 3355 (abs.)].

² The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.

³ To whom correspondence and reprint requests should be addressed.

⁴ Current address: Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108.

Manuscript received 19 January 1993. Revision accepted 28 June 1993.

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