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Journal of Nutrition Vol. 122 No. 8 August 1992, pp. 1614-1619
Copyright © 1992 by American Society for Nutrition
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Developmental Stages and Energy Restriction Affect Cellular Oncogene Expression in Tissues of Female Rats1

Myunggi Baik, Chang B. Choi, Wanda L. Keller and Chung S. Park2

Department of Animal and Range Sciences, North Dakota State University, Fargo, ND 58105

The influence of developmental stages and energy restriction on c-Ha-ras and c-fos cellular oncogene mRNA level was examined in mammary tissue and liver of female rats. c-Ha-ras and c-fos RNA transcripts in mammary tissue peaked at 9 wk of age, decreased during pregnancy, were lowest at mid-lactation and then increased at 25 wk. c-Ha-ras in liver showed highest expression at 5 wk and was hardly detectable at 11 wk, mid-pregnancy, mid-lactation and 25 wk. Liver c-fos and c-Ha-ras mRNA levels were similar. Lower c-Ha-ras and c-fos mRNA levels were observed in mammary tissue of energy-restricted (to 70% of ad libitum intake) rats at 25 wk compared with those allowed ad libitum access to food. Energy restriction did not affect liver c-Ha-ras and c-fos mRNA levels throughout the experimental period. These results demonstrate that developmental stages and energy restriction affect cellular oncogene mRNA levels with tissue-specific patterns.

KEY WORDS: • energy restriction • mammary development • liver • cellular oncogenes • rats

1 Presented in part at the 86th Annual Meeting of American Dairy Science Association, August, 1991, Logan, UT [Baik, M. G., Choi, C. B., Keller, W. L. & Park, C. S. (1991) Role of energy restriction in DNA methylation, gene and cellular oncogene expressions in rat mammary tissue. J. Dairy Sci. 74: 142 (abs.)].

2 To whom correspondence should be addressed.

Manuscript received 17 January 1992. Revision accepted 1 April 1992.






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