QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pfeuffer, M. Articles by Barth, C. A. Search for Related Content PubMed PubMed Citation Articles by Pfeuffer, M. Articles by Barth, C. A.

Dietary Sucrose but not Starch Promotes Protein-Induced Differences in Rates of VLDL Secretion and Plasma Lipid Concentrations in Rats

Institut für Physiologie und Biochemie der Ernährung, Bundesanstalt für Milchforschung, W-2300 Kiel 14, Germany

Casein instead of soybean protein in a low fat, cholesterol-free diet containing sucrose increases both lipid secretion by rat liver and plasma cholesterol concentration. Male rats were studied to determine whether dietary sucrose is a prerequisite for these protein-induced differences of lipid metabolism in vivo. After 6 wk of consuming either casein plus sucrose, soybean protein isolate plus sucrose, casein plus starch or soybean protein isolate plus starch (carbohydrate, 69 g/100 g diet; protein, 20 g/100 g diet) plasma lipids were measured. VLDL degradation was blocked by Triton WR-1339 and rates of lipid secretion were calculated from the observed linear increase in plasma levels with time. Plasma cholesterol concentrations and rates of secretion of VLDL cholesterol and triglycerides were 27, 47 and 34% higher, respectively, in animals fed casein plus sucrose compared with soybean protein plus sucrose. These differences were clearly diminished or absent when starch was the dietary carbohydrate. The data substantiate the finding that dietary sucrose but not dietary starch promotes a casein-induced increase in hepatic cholesterol secretion and thus contributes to casein-induced hypercholesterolemia in rats. On the contrary, differences of triglyceride secretion were not reflected in different plasma lipid concentrations.

KEY WORDS: • protein • cholesterol • rats • sucrose • VLDL

¹ To whom correspondence should be addressed.

Manuscript received 15 July 1991. Revision accepted 18 February 1992.

This article has been cited by other articles:

				M. K. Pickens, J. S. Yan, R. K. Ng, H. Ogata, J. P. Grenert, C. Beysen, S. M. Turner, and J. J. Maher Dietary sucrose is essential to the development of liver injury in the methionine-choline-deficient model of steatohepatitis J. Lipid Res., October 1, 2009; 50(10): 2072 - 2082. [Abstract] [Full Text] [PDF]

				D. Cao, H. Lu, T. L. Lewis, and L. Li Intake of Sucrose-sweetened Water Induces Insulin Resistance and Exacerbates Memory Deficits and Amyloidosis in a Transgenic Mouse Model of Alzheimer Disease J. Biol. Chem., December 14, 2007; 282(50): 36275 - 36282. [Abstract] [Full Text] [PDF]