QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Burrin, D. G. Articles by Gravitt, K. R. Search for Related Content PubMed PubMed Citation Articles by Burrin, D. G. Articles by Gravitt, K. R.

Porcine Colostrum and Milk Stimulate Visceral Organ and Skeletal Muscle Protein Synthesis in Neonatal Piglets¹

USDA/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, and Texas Children's Hospital, Houston, TX

Our objective was to determine the relative contributions of protein synthesis and protein absorption in the rapid accretion of gastrointestinal protein in suckling piglets during the early neonatal period. We measured the rates of tissue protein synthesis using a flooding dose of L-[4-³H]phenylalanine in various visceral and peripheral tissues of neonatal piglets fed water, mature milk or colostrum for 6 h. The jejunal and ileal protein synthesis rates in piglets fed either colostrum or milk were three- to fourfold higher than in piglets fed water. The increased jejunal and ileal protein synthesis could not, however, account for the differences in protein mass between the colostrum-fed and water-fed groups. The relative abundance of IgG, a major porcine colostral protein, in jejunal tissue was markedly higher in piglets fed colostrum than in piglets fed either milk or water. The fractional protein synthesis rates in liver, kidney, spleen and skeletal muscle and the absolute protein synthesis rates in liver and spleen were also greater in piglets fed colostrum than in those fed milk or water. Increased endogenous protein synthesis made only a minor contribution to the increased intestinal protein accretion in neonatal piglets fed colostrum. A much larger proportion of this increase seemed to be a result of absorption and retention of ingested immunoglobulins.

KEY WORDS: • colostrum • gastrointestinal tract • protein synthesis • neonatal • pigs

¹ This work is a publication of the USDA/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX. This project was funded in part with federal funds from the U.S. Department of Agriculture, Agricultural Research Service under Cooperative Agreement number 58-6250-1-003. The contents of this publication do not necessarily reflect the views or policies of the U.S. Department of Agriculture, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.

Manuscript received 11 October 1991. Revision accepted 8 January 1992.

This article has been cited by other articles:

				T. A. Davis, A. Suryawan, R. A. Orellana, H. V. Nguyen, and M. L. Fiorotto Postnatal ontogeny of skeletal muscle protein synthesis in pigs J Anim Sci, April 1, 2008; 86(14_suppl): E13 - E18. [Abstract] [Full Text] [PDF]

				K. E. Cowles, R. A. White, N. L. Whitehouse, and P. S. Erickson Growth Characteristics of Calves Fed an Intensified Milk Replacer Regimen with Additional Lactoferrin J Dairy Sci, December 1, 2006; 89(12): 4835 - 4845. [Abstract] [Full Text] [PDF]

				K. Rufibach, N. Stefanoni, V. Rey-Roethlisberger, P. Schneiter, M. G. Doherr, L. Tappy, and J. W. Blum Protein synthesis in jejunum and liver of neonatal calves fed vitamin A and lactoferrin. J Dairy Sci, August 1, 2006; 89(8): 3075 - 3086. [Abstract] [Full Text] [PDF]

				J. W. Frank, J. Escobar, A. Suryawan, H. V. Nguyen, S. R. Kimball, L. S. Jefferson, and T. A. Davis Dietary protein and lactose increase translation initiation factor activation and tissue protein synthesis in neonatal pigs Am J Physiol Endocrinol Metab, February 1, 2006; 290(2): E225 - E233. [Abstract] [Full Text] [PDF]

				A. M. Gaines, J. A. Carroll, G. L. Allee, and G. F. Yi Pre- and postweaning performance of pigs injected with dexamethasone at birth J Anim Sci, September 1, 2002; 80(9): 2255 - 2262. [Abstract] [Full Text] [PDF]