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Excessive Cholesterolemic Response in Analbuminemic Rats Fed a Cholesterol-Rich Diet Containing Casein¹

Xizhong Zhang^*,,, Jaap A. Joles^**, Hein A. Koomans^**, Arie van Tol^*** and Anton C. Beynen^,

^* Department of Nutrition and Food Hygiene, Shanxi Medical College, Taiyuan, Shanxi, The People's Republic of China Department of Laboratory Animal Science, State University, Utrecht, Department of Human Nutrition, Agricultural University, Wageningen ^** Department of Nephrology and Hypertension, University Hospital, Utrecht ^*** Department of Biochemistry I, Erasmus University, Rotterdam, The Netherlands

Female Nagase analbuminemic rats and Sprague-Dawley rats were fed purified diets with or without 1% cholesterol and containing either soybean protein or casein. After consuming the cholesterol-free diets, the analbuminemic rats had significantly higher plasma cholesterol and triglyceride concentrations than the Sprague-Dawley rats. The higher plasma cholesterol levels were essentially in the low density and high density lipoproteins. Based on the fact that the analbuminemic rats excreted more bile acids in feces it is possible that the higher baseline plasma cholesterol concentrations in Nagase analbuminemic rats were partly caused by overproduction of cholesterol. The Nagase analbuminemic rats displayed a greater cholesterolemic response to cholesterol feeding than Sprague-Dawley rats, but only if casein was the protein source in the diet. Casein vs. soybean protein in either cholesterol-free or high cholesterol diets reduced bile acid excretion in Sprague-Dawley but not in Nagase analbuminemic rats. The increased sensitivity to casein plus cholesterol feeding in Nagase analbuminemic rats may be caused by a lack of inhibition of de novo cholesterol synthesis.

KEY WORDS: • analbuminemia • dietary protein • dietary cholesterol • plasma cholesterol • rats

¹ Xizhong Zhang was supported by a 1988–1990 scholarship of the Shanxi Provincial Government, The People's Republic of China.

Manuscript received 28 May 1991. Revision accepted 2 October 1991.

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