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Artificial-Rearing Technique: Its Usefulness in Nutrition Research1

Mulchand S. Patel2 and Bhargava K. Hiremagalur

Departments of Biochemistry and Nutrition, Pew Center for Molecular Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH 44106

The rat model has been useful in determining the role of nutrients in such mammalian developmental processes as maturation of the brain and gastro-intestinal tract and metabolic adaptation in the liver. The suckling period, a critical time in early development, has been intractable to classical nutritional studies because of the necessity of the maternal involvement in rearing the pups. In this article, we review a promising technique in which rat pups are artificially reared through the use of an intragastric cannula connected to an automated pump that delivers a milk-substitute formula. We present relevant details of this technique, highlighting some of its advantages and limitations. Three metabolic processes in different organs are presented as examples of the usefulness of the artificial-rearing technique. This technique has high potential for a wider range of applications in nutritional assessment of macro- and micronutrients and in metabolic regulation in rats during the early postnatal period.

KEY WORDS: • artificial rearing technique • rats • milk-substitute formulas • premature induction of enzymes • hormonal changes

1 Supported by U.S. Public Health Service Grant HD 11089.

2 To whom correspondence should be addressed at Department of Biochemistry, Case Western Reserve University School of Medicine, 2119 Abington Road, Cleveland, OH 44106-4935.

Manuscript received 28 June 1991. Revision accepted 23 September 1991.






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