QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Arjmandi, B. H. Articles by Reeves, R. D. Search for Related Content PubMed PubMed Citation Articles by Arjmandi, B. H. Articles by Reeves, R. D.

Dietary Soluble Fiber and Cholesterol Affect Serum Cholesterol Concentration, Hepatic Portal Venous Short-Chain Fatty Acid Concentrations and Fecal Sterol Excretion in Rats¹

Department of Foods and Nutrition, Kansas State University, Manhattan, KS 66506

Sprague-Dawley rats were fed diets containing 7.5% dietary fiber as cellulose (control), pectin, psyllium or oat bran with or without 0.3% added cholesterol for 3 wk. Among rats fed cholesterol, liver total lipid and cholesterol concentrations were significantly lower in groups fed pectin, psyllium and oat bran compared with cellulose-fed controls. Cholesterol feeding resulted in significantly greater liver cholesterol in rats fed cellulose, psyllium and oat bran but not in those fed pectin. Among rats fed cholesterol, total serum cholesterol levels were significantly lower in those fed pectin than in those fed psyllium, oat bran or cellulose. When cholesterol was fed, the oat bran-fed group had significantly higher butyrate and the pectin-fed group had significantly higher propionate concentrations in the hepatic portal vein than did cellulose-fed controls. The groups fed psyllium, oat bran and pectin all had significantly higher fecal neutral sterols than did the cellulose-fed group when cholesterol was fed. Without dietary cholesterol only pectin-fed rats had significantly higher fecal excretion of neutral sterols than those fed cellulose. Dietary fiber did not influence fecal acidic sterol excretion. However, the addition of cholesterol to these fiber diets was accompanied by a significantly higher bile acid excretion than that of animals fed cellulose without cholesterol. The results of this study indicate that soluble dietary fibers may exert their hypocholesterolemic effect by increasing excretion of fecal neutral sterols.

KEY WORDS: • cholesterol • bile acids • fiber • rats

¹ Supported in part by American Heart Association, Kansas Affiliate, grant G-26 and the Kansas Agricultural Experiment Station, contribution no. 91-339-J from the Kansas Agricultural Experiment Station.

Manuscript received 4 February 1991. Revision accepted 26 July 1991.

This article has been cited by other articles:

				L. Perez-Olleros, M. Garcia-Cuevas, and B. Ruiz-Roso Nota. Influencia de la pulpa y fibra natural de algarrobas sobre algunos aspectos de la utilizacion nutritiva de la dieta y la colesterolemia en ratas / Note. Influence of pulp and natural carob fiber on some aspects of nutritional utilization and cholesterolemia in rats Food Science and Technology International, January 1, 1999; 5(5): 425 - 430. [Abstract] [PDF]