QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Wennberg, A. Articles by Lundholm, K. Search for Related Content PubMed PubMed Citation Articles by Wennberg, A. Articles by Lundholm, K.

Effects of Intravenous Nutrition on Lipoprotein Metabolism, Body Composition, Weight Gain and Uremic State in Experimental Uremia in Rats

Annika Wennberg, Hans-Erik Norbeck^*, Gunnar Sterner and Kent Lundholm^**,1

Kabi Nutrition, Stockholm, Sweden ^* King Gustav V Research Institute, Karolinska Hospital, Stockholm, Sweden Department of Medicine, University Hospital, Malmö, Sweden ^** Department of Surgery, Sahlgrenska Hospital, University of Gothenburg, Gothenburg, Sweden

The effect on serum lipids, lipoprotein fractions, body composition, weight gain and uremic state of including fat in intravenous nutrition was evaluated in rats with chronic uremia. Uremic rats were given high energy (1385 kJ·kg body weight^-1·day^-1), low nitrogen (0.6 g N·kg body weight^-1·day^-1) total parenteral nutrition (TPN) for 12 d with either glucose or glucose plus 30% lipids (Intralipid®) as the energy source. Additional uremic and nonuremic groups were fed a standard diet orally. During TPN, serum triglyceride and cholesterol levels were slightly higher in rats fed lipid-based TPN compared to those administered glucose-based TPN or fed the oral diet; but there were no differences 8 h after feeding. The serum lipoprotein fractions showed accumulation of lipids in LDL resulting from the lipid-based TPN but no differences in VLDL. In orally fed uremic rats, more lipids were found in HDL than in the TPN-treated rats. The fractional clearance of the fat emulsion was normal and independent of the nutrition composition. Uremic rats administered lipid-based TPN for 21 d had the same weight gain as orally fed, nonuremic control rats (23 ± 3 vs. 22 ± 2%); glucose-based TPN did not support normal growth (10 ± 1%). Uremic rats fed orally did not grow and retained significantly more body water than TPN-fed uremic rats. In uremic animals, lipid-based TPN also was associated with normal body composition despite significantly lower levels of carnitine in plasma, skeletal muscle and heart tissue. Complete intravenous nutrition with 30% of the nonprotein energy as fat and slightly reduced amino acids promoted normal weight gain and body composition and improved the uremic state. This did not occur in uremic rats either fed glucose-based TPN or a standard diet given orally.

KEY WORDS: • uremia • parenteral nutrition • lipoproteins • kidney • rats

¹ To whom correspondence should be addressed at: Department of Surgery, Sahlgrenska Hospital 413 45, University of Gothenburg, Gothenburg, Sweden.

Manuscript received 25 June 1990. Revision accepted 21 February 1991.