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Kinetics of Rat Peripheral Nerve, Forebrain and Cerebellum -Tocopherol Depletion: Comparison with Different Organs¹

INSERM U 26, Hôpital Fernand Widal, 200 rue du Faubourg Saint-Denis, 75475 Paris Cedex 10, France

Forty-two 60-d-old rats were fed a vitamin E-deficient diet for up to 8 wk and the kinetics of -tocopherol depletion were measured in nervous tissue and various organs. In most tissues examined, including the sciatic nerve but not the cerebellum, the disappearance was biphasic, suggesting the existence of two pools of vitamin E. In forebrain the disappearance was poorly biphasic. After an 8-wk period of vitamin E deprivation, forebrain, cerebellum, sciatic nerve endoneurium, liver, heart, muscle, testes and serum vitamin E concentrations were 51, 64, 65, 10, 20, 20, 40 and 19%, respectively, of initial values.

KEY WORDS: • vitamin E • -tocopherol • peripheral nerve • brain • rats

¹ Supported by l'Instítut National de la Santé et de la Recherche Médicale (INSERM), l'organisation Nationale Interprofessionnel des Oléagincux (ONIDOL) and le centre Technique Interprofessionnel des Oléagineux Métropolitains (CETIOM).

² To whom correspondence should be addressed.

Manuscript received 18 June 1990. Revision accepted 17 January 1991.