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The Hypocholesterolemic Effect of Dietary Soybean Protein vs. Casein in Hamsters Fed Cholesterol-Free or Cholesterol-Enriched Semipurified Diets

Department of Clinical Sciences, University of Lowell, Lowell, MA 01854

Golden Syrian hamsters fed a cholesterol-free diet containing 25% casein had higher plasma total triglyceride and cholesterol levels and VLDL + LDL cholesterol levels than animals fed a 25% soybean protein diet. Hamsters fed the cholesterol-free casein diet also had higher HDL cholesterol levels than animals fed the soybean protein diet, but these differences were not statistically significant. Addition of cholesterol to the diets caused even greater mean differences between the animals fed different types of protein, but the increased inter-animal variability of response to the added cholesterol resulted in less statistically significant differences. Although less responsive than the nonhybrid Golden Syrian hamsters, hybrid F₁B hamsters showed similar effects of dietary casein vs. soybean protein on plasma lipids. These results indicate that the hamster may be a useful model to examine the effect of different types of protein and the interaction with dietary cholesterol on various plasma lipids and lipoproteins.

KEY WORDS: • protein • cholesterol • casein • soybean protein • hamsters

Manuscript received 7 June 1990. Revision accepted 3 December 1990.

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