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Journal of Nutrition Vol. 121 No. 7 July 1991, pp. 925-933
Copyright © 1991 by American Society for Nutrition
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Alteration of Serum Lipoprotein Metabolism by Polychlorinated Biphenyls and Methionine in Rats Fed a Soybean Protein Diet1

Hiroaki Oda, Hideo Fukui, Yoshinori Hitomi and Akira Yoshida2

Laboratory of Nutritional Biochemistry, Department of Agricultural Chemistry, Nagoya University, Nagoya 464-01, Japan

The effects of dietary supplementation of methionine to a 20% soybean protein isolate diet on serum lipoprotein profiles and secretion rate of VLDL in rats receiving polychlorinated biphenyls (PCB) were investigated. Serum cholesterol levels were higher in rats fed PCB or a methionine supplement than in controls. The effects of PCB and methionine were synergistic. The feeding of PCB resulted in more cholesterol in all fractions of serum lipoproteins tested, especially HDL (HDL1 and HDL2). Dietary supplementation of methionine primarily increased HDL cholesterol. The elevation of serum lipoprotein cholesterol due to PCB and/or methionine was significant in HDL1, which showed {alpha}-mobility. These results showed that methionine and PCB significantly influenced HDL metabolism. The secretion rate of VLDL was higher in rats fed PCB than in controls, but the addition of methionine to diets did not affect the secretion rate of VLDL cholesterol. This implies that PCB increased serum cholesterol partly through the stimulation of VLDL cholesterol secretion.

KEY WORDS: • polychlorinated biphenyls • methionine • VLDL • HDL • rats

1 Supported in part by a grant from Elizabeth Arnold Fuji Foundation, Japan.

2 To whom correspondence should be addressed.

Manuscript received 5 February 1990. Revision accepted 21 November 1990.




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H. Oda
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J. Nutr., June 1, 2006; 136(6): 1666S - 1669S.
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