Journal of Nutrition Bio-Serv Delivering Solutions. . .

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Honeyfield, D. C.
Right arrow Articles by Froseth, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Honeyfield, D. C.
Right arrow Articles by Froseth, J. A.

Evaluation of Energy Sources with and without Carnitine in Newborn Pig Heart and Liver1

Dale C. Honeyfield and John A. Froseth

Department of Animal Sciences, Washington State University, Pullman, WA 99164-6320

The oxidation rate of five energy substrates with and without exogenous addition of camitine in the heart and liver of 15-h-old nonsuckled piglets was evaluated. Oxygen consumption (nmol O2·mg protein-1·min-1) in heart and liver for five substrates were: pyruvate, 0.248, 0.191; palmitoyl-CoA, 0.042, 0.034; palmitoyl-carnitine, 0.249, 0.111; isovalerate, 0.084, 0.059; acetoacetate, 0.166, 0.068, respectively. The addition of free carnitine doubled the rate of palmitoyl-CoA utilization in both heart and liver, but palmitoyl-CoA oxidation was always much lower than that of palmitoyl-carnitine. In livers of piglets from sows fed 8% fat, palmitoyl-carnitine oxidation was slower (P < 0.03) than in piglets from sows fed 0% fat. Heart tissue metabolized isovalerate faster (P < 0.02) when piglets were from sows fed fat compared with those from the nonfat group. A lysine x fat interaction was observed for piglet liver metabolism of isovalerate and acetoacetate, suggesting that a more metabolically developed pig results when sows are fed 0.48% lysine without supplemental fat during gestation. Carnitine did not seem to be the limiting factor for the oxidation of palmitoyl-CoA, and gestational dietary fat and lysine seemed to influence substrate metabolism in the newborn pig.

KEY WORDS: • piglets • fat • carnitine • lysine • mitochondria

1 College of Agriculture and Home Economics Research Center, Washington State University, Pullman, Project No. 0702, Paper No. 8014.

Manuscript received 13 March 1990. Revision accepted 26 November 1990.






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Copyright © 1991 by American Society for Nutrition