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Refeeding of Rats Fasted 36 Hours with Five Different Carbohydrates and with Malt Extract: Differential Effects on Glycogen Deposition in Liver and Muscle, on Plasma Insulin and on Plasma Triglyceride Levels

^* Department of Biochemistry, University of Basel, Vesalianum, Vesalgasse 1, CH-4051 Basel, Switzerland ^** Sandoz Nutrition, CH-3001 Bern, Switzerland

Rats fasted for 36 h were refed for 1, 2, 4 or 6 h with a diet containing 12 g/100 g casein, 2 g/100 g NaCl and 86 g/100 g glucose, fructose, maltose, sucrose, starch or malt extract. Blood glucose reached constant levels after 1 to 2 h of refeeding. The increase in plasma insulin paralleled food intake rather than the increase in blood glucose. Plasma triglycerides decreased upon refeeding starch, maltose and malt extract and increased with sucrose and fructose. Recovery of absorbed carbohydrates was highest in rats refed malt extract. Glycogen deposition in muscle was highest in rats fed malt extract and lowest in those fed fructose; sucrose yielded intermediate values. Glucose, maltose and starch resulted in muscle glycogen depositions slightly lower than those obtained with malt extract. In liver, sucrose and fructose were better precursors for glycogen than glucose and starch. With carbohydrates containing only glucose units, much more glycogen was found to be deposited in total muscle than in liver. This asymmetry was less notable or even was reversed with sucrose and fructose. Glycogen deposition in muscle and in liver is influenced by the carbohydrate used for refeeding, and muscle, rather than liver, is the main glycogen storing tissue.

KEY WORDS: • dietary carbohydrate • glycogen deposition • rats • plasma triglycerides • plasma insulin

Manuscript received 30 July 1990. Revision accepted 25 September 1990.