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Effects of Dietary Selenium and Fish Oil (MaxEPA) on Arachidonic Acid Metabolism and Hemostatic Function in Rats¹

Department of Nutrition and Food Management, Oregon State University, Corvallis, OR 97331

This study investigated whether hemostatic function can be modified by both the consumption of fish oil and the level of dietary selenium. Male Sprague-Dawley rats were fed for 8 wk semipurified diets containing 7% corn oil (by wt) or 5.5% fish oil (MaxEPA) plus 1.5% corn oil with or without selenium supplementation. Consumption of the four diets caused no difference in weight gain, food intake or plasma malondialdehyde content. The selenium-supplemented rats had significantly higher levels of selenium and glutathione peroxidase activity in plasma. Fish oil feeding decreased ADP-induced platelet aggregation and increased bleeding time. The level of dietary selenium and type of oil interacted to influence the production of 6-keto-prostaglandin F₁: more was produced when corn oil was fed in the selenium-deficient diets. These data suggest that the effect of dietary selenium on hemostatic function and the production of eicosanoids is minor.

KEY WORDS: • selenium • fish oil • elcosanoids • hemostatic function • rats

¹ This work was supported by the American Heart Association, Oregon Affiliate and the Animal Care and Use Committee of Oregon State University.

² To whom reprint requests should be sent.

Manuscript received 19 January 1990. Revision accepted 12 September 1990.

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