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Journal of Nutrition Vol. 121 No. 10 October 1991, pp. 1693-1698
Copyright © 1991 by American Society for Nutrition
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Dietary Soybean Isolate and Methionine Supplementation Affect Mammary Tumor Progression in Rats1

E. J. Hawrylewicz2, H. H. Huang and W. H. Blair

Department of Research, Mercy Hospital and Medical Center, Chicago, IL 60616

The effect of feeding soybean protein isolate (SBP) diet or soybean protein isolate diet supplemented with 0.7% DL-methionine (SBP+Met) on mammary tumor progression was investigated. Sprague-Dawley female rats were fed from weaning a 20% casein (CAS) diet supplemented with 0.3% DL-methionine (AIN-76) and injected via jugular vein with N-nitrosomethylurea (NMU, 40 mg/kg body weight) at 7 wk of age. Five weeks after NMU treatment, animals were divided into the three isoenergetic, isoprotein diet groups: CAS (25 rats); SBP (26 rats) and SBP+Met (25 rats). First palpable mammary tumors were evident 8, 9 and 13 wk and the mean latency period was 13.30 ± 1.23, 16.70 ± 1.32 and 17.82 ± 1.28 wk after NMU treatment in the CAS, SBP+Met and SBP diet groups, respectively. Tumor incidence was 80% in the CAS group compared with 42.3% in the SBP group (P = 0.01). Methionine supplementation increased tumor incidence to 64%. Total number and total weight of tumors was greater in the CAS group compared with either SBP+Met or SBP groups: 41 vs. 28 or 21 tumors and 97.28 g vs. 27.87 or 32.46 g, respectively. These data indicate that SBP diet, low in methionine content, fed 5 wk after carcinogen exposure significantly repressed mammary tumor progression. Methionine supplementation increased the number of animals with tumors but not the mean tumor weight.

KEY WORDS: • soybean protein • methionine • N-nitrosomethylurea • cancer • rats

1 Supported by the Bowyer Foundation, Chicago, IL.

2 To whom requests for reprints should be addressed.

Manuscript received 30 October 1990. Revision accepted 26 March 1991.




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