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Monsanto Company, Animal Sciences Division, St. Louis, MO 63198 * The University of North Carolina, School of Medicine, Chapel Hill, NC 27599
Six Holstein cows were used in a complete block design to examine effects of period of lactation and somatotropin (bST) administration on concentrations of insulin, insulin-like growth factors (IGF-I, IGF-II), and IGF-binding protein 2 (IGFBP-2). During late lactation, the dry period and the subsequent early lactation, cows received injections of NaHCO3 buffer for 5 d and bST for 7 d. Cows were in positive energy and protein balances during late lactation and the dry period and in slight negative balances during early lactation. Basal insulin concentrations were highest in late lactation (170 pmol/L), whereas bST concentrations were higher in early lactation (0.6 µg/L). Insulin was increased by bST in the dry period (255 pmol/L) and late lactation (149 pmol/L) but not in early lactation (14 pmol/L), probably because of greater availability of glucose during positive nutrient balance. Basal IGF-I was lowest in early lactation (63.6 µg/L) but was increased by bST during all periods. The IGF-I response to bST administration was lower during early lactation (74.1 µg/L) compared with late lactation (123.6 µg/L) and dry period (146.0 µg/L). The IGF-II concentrations were not affected by period of lactation of bST administration but IGF-II tended to be higher during bST administration when cows were dry. Concentration of IGFBP-2 was higher during early lactation when cows were in negative nutrient balance (479.5 µg/L) than during the dry period (289.2 µg/L) and was decreased with bST. These data support a role of insulin and IGF in regulation of milk production. Availability of nutrients may be involved in regulating these hormones, particularly during bST treatment.
KEY WORDS: • somatotropin • dairy cattle • nutrient balance • insulin-like growth factor • insulin
1 Presented in part at the 82nd Annual Meeting of the American Society of Animal Science (ASAS) in Ames, IA. [Vicini, J. L., Buonomo, F. C., Collier, R. J. & Clemmons, D. R. (1990) Response of insulin-like growth factor-binding protein 2 (IGFBP-2) to sometribove (bST, USAN) and stage of lactation in dairy cows. J. Anim. Sci. 68(Suppl. 1): 280–281 (abs.)] and the Joint Annual Meeting of the American Dairy Science Association and the ASAS in Lexington, KY. [Vicini, J. L., Buonomo, F. C., Miller, M. A., Hudson, S., Eppard, P. J. & Collier, R. J. (1989) Effects of lactation and nutrient balance on IGF-I response to daily somatotropin (sometribove, USAN) injection. J. Dairy Sci. 72(Suppl. 1): 327–328 (abs.)].
2 Present address: Food and Drug Administration, Center for Veterinary Medicine, Division of Toxicology, Rockville, MD 20857. This article was written by MAM in her private capacity. No official support or endorsement by the agency is, or should be, inferred.
Manuscript received 7 December 1990. Revision accepted 1 April 1991.
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