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Biotin Deficiency Per Se Is Teratogenic in Mice

Department of Hygiene and Preventive Medicine, Yamagata University School of Medicine, Yamagata, 990-23, Japan

We examined whether maternal biotin deficiency would potentiate the latent teratogenicity of relatively low doses of vitamin A in mice. The incidence and the type of gross congenital malformations (cleft palate, micrognathia, and micromelia) induced by biotin deficiency were similar among the groups given three different concentrations of vitamin A (4000, 12,000 and 60,000 KI) in the diet. Also, the type of these malformations was different from those (exencephaly, cleft palate and macroglossia) induced by a known teratogenic dose of vitamin A (1,200,000 KI). We conclude that in mice concentrations of vitamin A in the range of 4–10 times the level recommended by the National Research Council and biotin deficiency do not interfere with one another; also, biotin deficiency per se is teratogenic in mice.

KEY WORDS: • biotin deficiency • vitamin A • teratogenicity • mice

Manuscript received 21 February 1990. Revision accepted 5 June 1990.