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Accumulation in Chick Livers of 9-cis Versus All-trans ß-Carotene¹

Shoshana Mokady, Mordhay Avron^* and Ami Ben-Amotz

Department of Food Engineering and Biotechnology, Technion, Haifa 32000, Israel ^* Department of Biochemistry, The Weizmann Institute of Science, Rehovot 76100, Israel National Institute of Oceanography, Israel Oceanographic & Limnological Research, Tel-Shikmona, Haifa 31080, Israel

Previous results indicated that ß-carotene, as present within the unicellular alga Dunaliella, accumulated in the liver of chicks to a much higher degree than did synthetic all-trans ß-carotene. Because the Dunaliella ß-carotene is composed of an approximately equal mixture of two stereoisomers, 9-cis and all-trans, we tested whether a similar mixture of purified ß-carotene isomers would yield comparable results. Indeed, analysis of liver following 2 wk of feeding show a 10-fold higher accumulation of ß-carotene in the chicks fed a mixture of purified 9-cis and all-trans ß-carotene as compared with those fed only all-trans ß-carotene. The ratio of 9-cis to all-trans ß-carotene in the liver was about three times higher than that present in the ß-carotene fed to the chicks. Retinol and retinyl esters accumulated to a similar degree in the livers of chicks given all treatments.

KEY WORDS: • Dunaliella • ß-carotene isomers • liver storage • chicks

¹ Supported in part by the Stauss/Hanauer Memorial Fund, Inc.

Manuscript received 29 September 1989. Revision accepted 2 February 1990.

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