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Long-Chain Fatty Acid Composition of Maternal Liver Lipids during Pregnancy and Lactation in the Rat: Comparison of Triglyceride to Phospholipid¹

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada M5S 1A8

The change in long-chain fatty acid composition in maternal liver was studied during pregnancy and lactation in the rat. Maternal liver triglycerides and phospholipids transiently accumulated and were depleted of long-chain fatty acids during pregnancy and lactation. During pregnancy, maternal liver accumulated triglyceride, but triglyceride fatty acid composition changed little. However, maternal liver total phospholipid fatty acid composition changed significantly without a change in the total pool size throughout pregnancy or lactation. The change in composition of (n-3) and (n-6) essential fatty acids in maternal liver triglyceride and total phospholipid occurred in an apparently dyssynchronous manner throughout pregnancy and lactation.

KEY WORDS: • pregnancy • lactation • unsaturated fatty acids • hepatic lipids • rat

¹ Supported by the Natural Sciences and Engineering Research Council of Canada.

² Career Scientist of the Ontario Ministry of Health, to whom reprint requests should be addressed.

Manuscript received 2 May 1989. Revision accepted 3 October 1989.

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