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Dose-Response Tests in Field Surveys^1,2,

National Eye Institute, National Institutes of Health, Bethesda, MD 20892

Single static biochemical measures that are commonly used in field surveys often do not capture the dynamic metabolic situation that is most closely related to nutritional status. In contrast, short-term dose-response tests provide more reliable information about nutritional status for some nutrients, but not for others. In vivo response tests for vitamin A and for iron are promising, and in vitro enzyme stimulation tests for thiamin, riboflavin, pyridoxine, and selenium have been widely used. In vivo response tests are constrained by the needs for a waiting period, often for two or more biological samples, and usually for sophisticated instrumentation. In large field surveys, dose-response tests may be best used on a subsample of the population studied.

KEY WORDS: • nutritional assessment • biochemical analysis • dose-response tests • vitamin A • iron • water-soluble vitamins

¹ Presented as part of a conference, "Nutrition Monitoring and Nutrition Status Assessment", at the first fall meeting of the American Institute of Nutrition, Charleston, South Carolina, December 8–10, 1989. The conference was supported in part by cooperative agreement HPU880004-02-1 with the DHHS Office of Disease Prevention and Health Promotion, the USDA Human Nutrition Information Service, the DHHS National Center for Health Statistics, and the International Life Sciences Institute-Nutrition Foundation.

² The Planning Committee for the meeting consisted of Drs. Helen A. Guthrie, Roy J. Martin, Linda D. Meyers, James A. Olson, Catherine E. Woteki, and Richard G. Allison (ex officio). The symposium papers were edited by a committee consisting of Dr. James Allen Olson (coordinator), Dept. of Biochemistry & Biophysics, Iowa State University, Ames, IA; Dr. Cathy C. Campbell, Division of Nutritional Sciences, Cornell University, Ithaca, NY; Dr. Roy J. Martin, Dept. of Foods & Nutrition, University of Georgia, Athens, GA; and Dr. Catherine E. Woteki, Food & Nutrition Board, National Academy of Sciences, Washington, DC.

Manuscript received 10 December 1989. Revision accepted 11 July 1990.

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