QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Gallaher, D. D. Articles by Franz, P. M. Search for Related Content PubMed PubMed Citation Articles by Gallaher, D. D. Articles by Franz, P. M.

Effects of Corn Oil and Wheat Brans on Bile Acid Metabolism in Rats^{1, 2,}

Department of Food and Nutrition, North Dakota State University, Fargo, ND 58105

High concentrations of colonic bile acids may promote tumor formation. Some studies have found that high levels of dietary fat increase fecal bile acid excretion, whereas others report no effect. Wheat bran appears to reduce fecal bile acid concentration. This study was conducted to determine the effect of different dietary fat levels and types of wheat bran on bile acid metabolism. Rats were fed diets containing either no fiber, 2% cholestyramine (CHO) or brans of hard red spring, soft white winter or durum wheat—at both a 5 or 20% fat level. Animals were fed for 7 wk, and feces were collected in the last week. Wheat bran (all types) significantly increased fecal mass approximately fourfold, and CHO significantly increased fecal mass twofold compared to the fiber-free diet. Increasing the fat level did not increase fecal bile acid excretion, nor did the addition of wheat bran. Addition of CHO, however, more than doubled it. CHO increased fecal bile acid concentration, all wheat brans decreased it and fat level had no effect. Bile acid pool size was increased slightly by fat level and cholestyramine feeding but not by wheat brans. These results indicate that fat level slightly alters bile acid metabolism but that wheat brans do not.

KEY WORDS: • bile acids • dietary fiber • dietary fat • cholestyramine • rats

¹ Presented in part at the 72nd Annual Meeting of the Federation of American Societies for Experimental Biology, Las Vegas, NV, May 1–5, 1988 [FRANZ, P. & GALLAHER, D. (1988) Effect of wheat brans and fat level on bile acid metabolism in the rat. FASEB J. 2: A1414 (abs.)].

² This investigation was supported by Public Health Service grant number CA 40843 awarded by the National Cancer Institute, Department of Health and Human Services.

³ Present address: Department of Food Science and Nutrition, 1334 Eckles Avenue, University of Minnesota, St. Paul, MN 55108.

⁴ To whom reprint requests should be sent.

Manuscript received 23 August 1989. Revision accepted 8 June 1990.