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Journal of Nutrition Vol. 120 No. 10 October 1990, pp. 1205-1213
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Distribution of [14C]Canthaxanthin and [14C]Lycopene in Rats and Monkeys1

Micheline M. Mathews-Roth2,*, Sudha Welankiwar**, Prabhat K. Sehgal{dagger}, Niels C. G. Lausen{ddagger}, Mark Russett** and Norman I. Krinsky**

* Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, MA 02115 ** Department of Biochemistry, Tufts University School of Medicine, Boston, MA 02111 {dagger} New England Regional Primate Center, Southboro, MA 01772 {ddagger} Department of Comparative Pathology, Harvard Medical School, Boston MA 02115

The absorption and distribution of [14C]-canthaxanthin and [14C]lycopene were studied in rats and in rhesus monkeys following the oral administration of [14C]canthaxanthin or [14C]lycopene in olive oil supplemented with 1 mg {alpha}-tocopherol/mL. For canthaxanthin and lycopene, peak accumulation of radioactivity in plasma occurred between 4 and 8 h in rats and between 8 and 48 h in monkeys. In rats, the liver contained the largest amount of both kinds of radioactive pigments. In monkeys, with the exception of one stomach sample, liver was also the major depot organ for both canthaxanthin and lycopene. The other organs tested accumulated various amounts of pigment. No labeled metabolic products of either canthaxanthin or lycopene were found.

KEY WORDS: • canthaxanthin • lycopene • metabolism • rats • monkeys

1 This work was supported by grant U01 CA39967 from the National Cancer Institute (to M. M-R.).

2 To whom reprint requests should be sent.

Manuscript received 16 November 1989. Revision accepted 21 May 1990.






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