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The Effect of Polyneuritis in Chicks upon the in Vivo Rate of Removal of Pyruvate Injected Intravenously¹

One Figure

Department of Agricultural Chemistry, University of Wisconsin College of Agriculture, Madison

1. The bisulphite-binding substances of normal and B avitaminous chick blood and feces have been investigated. Intravenous injections of sodium pyruvate were made in normal and polyneuritic chicks, and its rate of removal from the blood determined.

2. There is no rise in the bisulphite-binding substances of the blood of chicks in avitaminosis B, but the excreta of poly-neuritic chicks contain increased amounts of bisulphitebinding substances.

3. Pyruvate injected intravenously is very rapidly removed from the blood of normal chicks. A slow rate of removal was found in polyneuritic chicks.

4. These phenomena are consistent with the view that in polyneuritis there is a failure in the tissue metabolism of pyruvic acid.

Manuscript received 8 June 1936.

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