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Journal of Nutrition Vol. 119 No. 9 September 1989, pp. 1327-1332
Copyright © 1989 by American Society for Nutrition
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Influence of Fecal Anorexigenic Substance (FS-T) on Plasma Amino Acids in Wistar and Zucker Obese (fa/fa) Rats

Tomi T. Tsuda, Tomoichi Ohkubo, Hiroshi Kamiguchi*, Michio Tsuda, Tsunehiko Katsunuma1 and Masaichi Yamamura

Department of Biochemistry, School of Medicine * Division of Biochemistry, Interdepartmental Laboratory, Tokai University, Isehara, Kanagawa, Japan 259-11

An anorexigenic substance (FS-T), found in feces, isolated and injected intraperitoneally, induced significant feeding suppression in Wistar rats and in genetically obese Zucker rats (fa/fa) and their lean littermates. The concentration of total plasma amino acids 2 h after FS-T injection (the time of maximum feeding suppression) was 71.0, 68.6 and 60.2% of that of controls for Wistar and Zucker obese and lean rats, respectively. By 48 h after injection of FS-T, food intake and the concentration of total plasma amino acids had returned to normal. Plasma tryptophan levels and the ratio of tryptophan to neutral amino acids were also monitored to elucidate the relation between FS-T and appetite. Two h after injection of FS-T, the ratio of tryptophan to neutral amino acids had increased in Wistar rats, while no change was detected in either obese or lean Zucker rats. However, no change was observed in plasma glucagon levels in Wistar rats, but a significant increase was found in both obese and lean Zucker rats at 2 h after FS-T injection.

KEY WORDS: • fecal anorexigenic substance (FS-T) • Wistar rat • Zucker obese (fa/fa) rat • Zucker lean rat • feeding suppression • plasma amino acids • tryptophan/neutral amino acids ratio • glucagon • insulin

1 T. Katsunuma died prior to publication of this manuscript.

Manuscript received 29 March 1988. Revision accepted 17 April 1989.






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