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Molecular Biology and Nutrition Research^1,2,

Richard W. Hanson, Maria Hatzoglou, Mary M. McGrane, Anthony Wynshaw-Boris⁺, Fritz M. Rottman and Thomas Wagner^*

The Pew Center for Molecular Nutrition Department of Biochemistry Department of Molecular Biology ⁺ Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH 44106 ^* The Edison Animal Biotechnology Center, Ohio University, Athens, OH 45701

The important advances that have occurred in molecular and cell biology have great potential for metabolic and nutritional research. This review will focus on the application of genetic manipulation to metabolism and nutrition, with special emphasis on the tissue-specific expression and regulation of the newly introduced genes.

KEY WORDS: • transgenic animals • chimeric genes • retroviral vector • gene therapy • metabolic patterning

¹ Supported in part by funds from the Pew Charitable Trust and the Thomas Edison Project of the State of Ohio and by grants DK-21859 and DK-24551 (RWH) and DK-09042 (TW) and KD-32770 (FMR) from the National Institutes of Health. M.M.M. and A.W-B. were Trainees of the Metabolism Training Program AM-07139, from the National Institutes of Health.

² This article is based on a presentation made in Washington, D.C., at the Food and Nutrition Board annual symposium, Frontiers in Nutrition Science, December, 1987.

Manuscript received 21 December 1988. Revision accepted 17 April 1989.