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Dietary Selenium Intake Controls Rat Plasma Selenoprotein P Concentration^1,2,

Division of Gastroenterology, Department of Medicine and Center in Molecular Toxicology, Vanderbilt University School of Medicine and Veterans Administration Medical Center, Nashville, TN 37232 and Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78284

The purpose of this study was to determine the effect of dietary selenium on selenoprotein P concentration. Selenoprotein P was quantitated in plasma by radioimmunoassay. Selenium-dependent glutathione peroxidase activity in plasma and liver 105,000 x g supernatant was measured for comparison. Weanling male rats were fed a selenium-deficient diet or a control diet that contained 0.5 mg selenium/kg as Na₂SeO₄. The concentration of selenoprotein P fell at approximately the same rate in the rats fed the selenium-deficient diet as did plasma glutathione peroxidase activity. Groups of weanling rats were fed different levels of selenium for 8 wk. Selenoprotein P concentration was proportional to dietary selenium level up to 0.1 mg/kg and was a greater percentage of control values than was glutathione peroxidase activity. No increment in selenoprotein P concentration occurred between 0.1 and 0.5 mg selenium/kg diet. These results indicate that the concentration of selenoprotein P in the plasma is directly dependent on selenium supply in the diet up to 0.1 mg/kg. There is overlap between the dietary selenium ranges in which selenoprotein P concentration and glutathione peroxidase activity increase, but the selenoprotein P range is lower than the glutathione peroxidase range.

KEY WORDS: • selenium • selenoprotein P • glutathione peroxidase • rat

¹ Supported by National Institutes of Health Grant ES 02497.

² Presented at the 72nd Annual Meeting of the Federation of American Societies for Experimental Biology, May 3, 1988 [FASEB J. 2: A1088 (abs.)].

³ To whom reprint requests should be sent at: Medical Center North, C-2104, Vanderbilt Medical Center, Nashville, TN 37232.

Manuscript received 27 October 1988. Revision accepted 28 March 1989.

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