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Relative Effects of Dietary Oleic- and Linoleic-Rich Oils on Plasma Lipoprotein Composition in Rats^1,2,

Department of Nutritional Sciences, College of Agricultural and Life Sciences, University of Wisconsin, Madison, WI 53706

Plasma lipoprotein composition and hepatic lipid content were investigated in male Sprague-Dawley rats (104 ± 2 g) fed diets containing 12% olive oil [OO, 70% 18:1(n-9)], 12% high oleic safflower oil [SO, 70% 18:(ln-9)] or 12% high linoleic safflower oil [SL, 73% 18:2(n-6)] for periods of up to 10 wk. Fasting plasma triglycerides were significantly higher after feeding oleic-rich diets than after feeding SL for 3, 5 and 6 wk. At 6 wk VLDL triglycerides were two- to threefold higher in rats fed OO or SO than in those fed SL, but by 10 wk both plasma and VLDL triglycerides were similar. A greater proportion of HDL₂ (diameter 8.0–12.1 nm), a lower proportion of HDL₁ (diameter 12.2–17.0 nm) and lower HDL apo E content occurred in rats fed OO and SO than in those fed SL at both 6 and 10 wk. LDL and HDL protein and cholesterol concentrations were not different with feeding SO or SL. After 10 wk of feeding the experimental diets, rats fed OO had significantly lower HDL protein, cholesterol and apo E concentrations and significantly higher hepatic triglyceride content compared to rats fed SO or SL, P < 0.05. These data suggest that HDL and hepatic lipid content are determined by some property of the dietary oil other than its oleic acid content.

KEY WORDS: • oleic acid • linoleic acid • oliver oil • triglycerides • VLDL • HDL • apo E • cholesterol • rat

¹ Supported by funds from the College of Agricultural and Life Sciences, University of Wisconsin-Madison, project #3096, and National Institutes of Health Training Grant No. 5T32CAO9451.

² Part of this work was published as an abstract: Lasekan, J. B. and Ney, D. M. (1988) Altered triglyceride and HDL responses in growing rats fed linoleic- or oleic-rich oils. FASEB J. 2(4): A425 (abs. 755).

³ Present address: Department of Food and Nutrition, Sook Myung Women's University, Chungpa—Dong 2Ka, Youngsan-Ku, Seoul, Korea.

Manuscript received 28 November 1988. Revision accepted 14 February 1989.