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Journal of Nutrition Vol. 119 No. 4 April 1989, pp. 639-646
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Zinc Uptake by Basolateral Membrane Vesicles from Rat Small Intestine1

Paul Oestreicher2 and Robert J. Cousins3

Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611

Zinc uptake (transport and binding) by basolateral membrane vesicles was investigated using membranes derived from small intestines of rats fed zinc-adequate and zinc-deficient diets. Uptake was separated into saturable and nonsaturable (diffusion) components. Kinetic analysis of initial rates of the saturable component of uptake (at 1 min) indicates half maximal uptake (Km) by vesicles from zinc-adequate rats was observed at a medium Zn2+ concentration of 24 µM. The maximum Zn2+ uptake rate (Jmax) of the saturable component was 17 nmol/(mg protein·min). Dietary zinc intake did not affect these parameters. Zn2+ transport by the basolateral membrane may involve an ATP-driven mechanism.

KEY WORDS: • zinc • absorption • active transport • kinetics • basolateral membranes

1 Supported by National Institutes of Health Grant DK 31127 and by endowment funds from the Institute of Food & Agricultural Sciences.

2 Present address: Public Policy and Communications, Hoffmann-La Roche Inc., Nutley, NJ 07110.

3 To whom reprint requests should be addressed.

Manuscript received 15 July 1988. Revision accepted 5 January 1989.




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