Journal of Nutrition

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Journal of Nutrition Vol. 119 No. 3 March 1989, pp. 439-445
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Effects of Iron Deficiency on Metallothionein-I Concentrations in Blood and Tissues of Rats1 ,2

Aileen Robertson3, James N. Morrison, Anne M. Wood and Ian Bremner

Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB, United Kingdom

The effects of iron deficiency and of restriction of food intake on blood and tissue metallothionein-I (MT-I) concentrations in rats were investigated. Compared to ad libitum fed controls, MT-I concentrations in the blood cells of the iron-deficient rats were higher, whereas concentrations in pair-fed control rats were lower. Iron deficiency also increased MT-I concentrations in the bone marrow but concentrations in the liver were unchanged and those in the kidneys were reduced. The MT-I in the blood cells was associated mainly with the lighter cell fractions which were rich in reticulocytes. It is suggested that concentrations of MT-I in blood cells reflect erythropoietic activity.

KEY WORDS: • metallothionein • iron deficiency • starvation • erythrocyte • reticulocyte

1 Supported in part by a grant to A. Robertson from the Scottish Home and Health Department, Edinburgh.

2 Presented in part at a meeting of the Nutrition Society, Aberdeen, September 1987.

3 Present address: Dept of Nutrition and Dietetics, Raigmore Hospital, Inverness, Scotland.

Manuscript received 9 February 1988. Revision accepted 10 October 1988.




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