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The Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104
This study was designed to determine the degree of energy restriction necessary to achieve significant inhibition of mammary tumor promotion in rats treated with 7,12-dimethylbenz[a]anthracene (DMBA). A control group of rats was fed a diet containing 5% corn oil and libitum. Four other groups were pair-fed to the controls; these rats were subjected to energy restriction of 10, 20, 30, or 40%. Weight gains among the groups were proportional to energy intake. The differences in weight were due primarily to reductions in body fat stores. Tumor incidence was reduced slightly by 20% calorie restriction and significantly by 30 and 40% restriction. There were also reductions in number of tumors per tumor-bearing rat and in mean tumor weight. The groups subjected to 30 and 40% energy restriction had significantly reduced serum levels of insulin in the fasting state. These data suggest that body weight, body fat, and fasting serum insulin correlate with susceptibility to mammary tumor promotion and that insulin may be a growth factor for DMBA-induced tumors.
KEY WORDS: • mammary cancer • insulin • dietary fat • energy • body weight
1 Supported in part by grants from the American Institute for Cancer Research, Best Foods, and Research Career Award HL-00734 from the National Institutes of Health.
Manuscript received 16 May 1988. Revision accepted 26 September 1988.
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