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Influence of Chronic Energy Intake Restriction on Intestinal Alkaline Phosphatase in C3H/Bi Mice and Autoimmune-Prone MRL/lpr,lpr Mice1

My Lien Dao, Ruping Shao, Jon Risley and Robert A. Good2

University of South Florida, All Children's Hospital, St. Petersburg, FL 33701

The influence of chronic energy intake restriction (CEIR) on the level and activity of intestinal alkaline phosphatase was investigated in mice of the autoimmuneprone MRL/lpr,lpr strain and in mice of the autoimmune-resistant C3H/Bi strain. In both strains of mice, CEIR of 40% resulted in a significant increase in intestinal alkaline phosphatase (IAP) specific activity in MRL/lpr,lpr mice after 10 wk of feeding, and in C3H/Bi mice after 6 wk of feeding. An increase in the amount of immunoreactive alkaline phosphatase antigen was also found to be associated with the increased enzyme activity in CEIR mice. These results suggest that a specific induction of an intestinal enzyme occurs or, alternatively, that there is a specific relative decrease in synthesis of intestinal proteins other than IAP as a function of CEIR. Thus, CEIR appears to regulate the expression of proteins in the small intestine in a specific manner.

KEY WORDS: • energy restriction • small intestine • alkaline phosphatase • enzyme regulation • mice

1 Supported in part by grants from the Ronald Mcdonald Children's Charities and the Florida Chapter of the American Heart Association, and by Public Health Service grants no. AG05633 and DE07836 from the National Institutes of Health.

2 To whom correspondence should be addressed.

Manuscript received 9 December 1988. Revision accepted 24 July 1989.






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