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Interactions of Lactose with Calcium, Magnesium and Zinc in Rats¹

Department of Nutritional Sciences, University of Wisconsin, Madison, WI 53706

The effects of lactose on utilization of calcium, magnesium and zinc were examined in two studies. In study 1, weanling male rats were fed either nonfat dry milk or CaHPO₄, dolomite or a calcium chelate with supplemental lactose or sucrose for 27 d. In study 2, weanling male rats were fed diets based on milk or lactose-hydrolyzed milk for 28 d or in one meal labeled with ⁴⁵Ca. Rats fed the lactose-hydrolyzed milk rather than the untreated milk digested their diet more completely, apparently absorbed total calcium and ⁴⁵Ca less efficiently, and lost more calcium in urine but retained similar amounts of total calcium and ⁴⁵Ca in bone. The effect of lactose hydrolysis on the absorption of ⁴⁵Ca was similar whether rats were fed only one meal of the milk-based diets or were fed the diets chronically. The rats fed supplemental lactose (study 1) or unhydrolyzed milk (study 2) retained more magnesium and zinc in bone.

KEY WORDS: • lactose hydrolysis • calcium • magnesium • zinc • milk • calcium absorption • radioactive isotopes • weanling male rats

¹ Supported by the College of Agricultural and Life Sciences, University of Wisconsin-Madison project #2623 and by the Wisconsin Milk Marketing Board in association with the National Dairy Council.

Manuscript received 2 May 1989. Revision accepted 20 June 1989.