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Search for Role of Milk-Borne Biologically Active Peptides for the Suckling¹

Otakar Koldovsk

Departments of Pediatrics and Physiology, Section of Neonatology and Nutritional Sciences and Children's Research Center, University of Arizona College of Medicine, Tucson, AZ 85724

Milk contains a significant number of substances having peptide characteristics that are known to possess biological activity. The possible physiological importance for the neonate is discussed in this review in light of their effects (epidermal growth factor, nerve growth factor, insulin, prolactin, somatostatin, thyroid-releasing hormone, thyroid-stimulating hormone, growth hormone-releasing factor, luteinizing hormone-releasing hormone, adrenocorticotrophic hormone, erythropoietin, bombesin-like peptides, calcitonin, ß-casomorphins and delta-sleep-peptides) on suckling mammals after gastrointestinal administration.

KEY WORDS: • hormones • milk • suckling

¹ Supported by National Institutes of Health Grant No. DK27624.

Manuscript received 17 March 1989. Revision accepted 14 August 1989.

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