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Journal of Nutrition Vol. 119 No. 1 January 1989, pp. 75-81
Copyright © 1989 by American Society for Nutrition
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Effects of Aspartame and Carbohydrate Administration on Human and Rat Plasma Large Neutral Amino Acid Levels and Rat Brain Amino Acid and Monoamine Levels

M. Romano, F. Casacci*, F. de Marchi*, T. Pacel*, A. Esteve, G. Lomuscio, T. Mennini and M. Salmona

* Laboratory for Enzyme Research Istituto di Ricerche Farmacologiche "Mario Negri," Milan, Italy and Divisione Ricerca e Sviluppo, Pierrel S.P.A., Milan, Italy

Thirty fasted human volunteers were given 0.83 and 8.3 mg aspartame/kg body weight alone, as part of a basal low carbohydrate meal (648 kcal, 10% carbohydrate) or as part of a high energy carbohydrate-rich meal (1290 kcal, 34% carbohydrate). Amino acid concentrations in plasma were determined before and 30, 60 and 180 min after the consumption of aspartame. Under these conditions, which mimic realistic aspartame consumption, aspartame had no significant effect on plasma concentration of any amino acid. In addition, the effect of aspartame alone or with carbohydrates on plasma and brain amino acid levels was studied in rats after acute or subacute (14 d) oral treatment. In subacute dosing experiments aspartame was included in the diet. Brain monoamine concentrations were also measured in the same animals. Plasma concentrations of large neutral amino acids were modified under acute conditions. In contrast, after subacute treatment no significant differences in plasma or brain amino acid concentrations or in brain monoamine concentrations were observed.

KEY WORDS: • aspartame • carbohydrates • amino acids • monoamines

Manuscript received 18 February 1987. Revision accepted 28 April 1988.






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