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Effect of Protein Level and Protein Source on Zinc Absorption in Humans

Brittmarie Sandström^*,2, Annette Almgren^*, Barbro Kivistö^* and Åke Cederblad

^* Department of Clinical Nutrition and Radiation Physics, University of Gothenburg, S-413 45 Gothenburg, Sweden

The effect of increasing levels of various protein sources on zinc absorption from a legume-based meal was studied in humans with the use of a radionuclide technique. The meals were extrinsically labelled with ⁶⁵Zn and absorption was determined from measurements of the whole-body retention of the isotope. The mean fractional zinc absorption for the 13 meals was 24.7 ± 6.9% and was only influenced by the protein content of the meal to a limited extent (r = 0.45). However, the amount of zinc absorbed from the meals was strongly correlated with both the protein (r = 0.85) and zinc content (r = 0.86): 5.9 ± 1.7 µmol of zinc was absorbed from the basal bean meal which had the lowest protein content; the addition of low zinc chicken doubled the protein content and increased zinc absorption to 10.3 ± 2.0 µmol; the addition of zinc-rich beef also doubled the protein content, however, zinc absorption was increased to 15.9 ± 4.7 µmol. It is concluded that the zinc content of the main protein source of the diet determines the amount of zinc absorbed to a large extent. However, relatively small amounts of animal protein can significantly improve the value of a legume-based meal as a source of zinc.

KEY WORDS: • zinc absorption • ⁶⁵Zn • animal protein • phytic acid • human

² To whom correspondence should be addressed. Present address: Research Department of Human Nutrition, Rolighedsvej 25, DK-1958 Fredriksberg, Denmark.

Manuscript received 14 July 1988. Revision accepted 14 September 1988.

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