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INSERM Unité 26, Hôpital Fernand Widal, 75075 Paris Cedex 10, France
Rats were fed a purified diet containing either 1.5% sunflower oil [940 mg linoleic acid [18:2(n-6)]/100 g diet; 6 mg 
-linolenic acid [18:3(n-3)]/100 g diet] or 1.9% soybean oil [940 mg 18:2(n-6)/100 g diet; 130 mg 18:3(n-3)/100 g diet]. In all cells and tissues examined 22:6(n-3) was lower and 22:5(n-6) was higher in rats fed sunflower oil than in rats fed soybean oil. Levels of 22:4(n-6) and 20:4(n-6) were largely unaffected. Expressed as a percentage of that in soybean oil-fed rats, 22:6(n-3) in sunflower oil-fed rats was as follows: neurons, 49; astrocytes, 47; oligodendrocytes, 10; lung, 27; testes, 32; retina, 36; liver, 35 and kidneys, 45. Ten wk after the change in diet of 60-d-old rats from one containing sunflower oil to one containing soybean oil, the fatty acid composition of the brain cells had not reached control values, e.g., that obtained in animals continuously fed soybean oil; 22:6(n-3) was 77, 65 and 80% of control levels for astrocytes, oligodendrocytes and neurons, respectively. In contrast, the recovery measured by the decay of 22:5(n-6) was complete within 10 wk. For 22:6(n-3), it took approximately 2 wk for liver and kidney to recover to the control value, 3 wk for lung, 6 wk for retina and 10 wk for testes. The decrease of 22:5(n-6) was rapid: the control values were reached within 2 wk for kidney, liver and lung and within 6 wk for retina. Because the recovery of the content of 22:6(n-3) by brain cells was very slow, the optimal ratio of long-chain fatty acid precursors must be determined very carefully.
KEY WORDS: • polyunsaturated fatty acids • neuron • astrocyte • oligodendrocyte • brain
1 This work was supported by l'Institut National de la Santé et de la Recherche Médicale (INSERM) and le Centre Technique Interprofessionnel des Oléagineux Métropolitains (CETIOM).
Manuscript received 16 December 1986. Revision accepted 23 May 1988.
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