QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Moon, R. C. Search for Related Content PubMed PubMed Citation Articles by Moon, R. C.

Comparative Aspects of Carotenoids and Retinoids as Chemopreventive Agents for Cancer¹

IIT Research Institute, Life Sciences Research, Chicago, IL 60616

Retinoids are well established chemopreventive agents for experimental carcinogenesis of many target organs including mammary gland, urinary bladder, lung, skin, liver, pancreas, colon and esophagus. Modification of the basic retinoid structure has produced analogs with enhanced target organ specificity, increased inhibitory activity and reduced toxicity. N-(4-hydroxyphenyl) retinamide (4-HPR) currently appears to be the most efficaceous retinoid against carcinogen-induced breast, urinary bladder, and lung cancer in rodents. Retinoids are most effective when administered shortly after the carcinogen treatment; however, the treatment can be delayed significantly while maintaining its chemopreventive effect. Under various experimental conditions, combining retinoid treatment with other modifiers of growth enhances its chemopreventive activity; for example, retinoid plus hormonal modulation can provide better protection against mammary cancer than either treatment alone. The role of carotenoids in cancer chemoprevention is less well defined. Studies have been complicated by the poor absorption and low tissue levels of carotenoids in the rodent models used for such studies. Aside from experimental skin carcinogenesis, little information is available relative to the effect of carotenoids on the chemoprevention of cancer at other organ sites.

KEY WORDS: • retinoids • carotenoids • chemoprevention • cancer • animal models

¹ Presented as part of the symposium, "Biological Actions of Carotenoids," given at the 72nd annual meeting of the Federation of American Societies for Experimental Biology, Las Vegas, NV, May 2, 1988, and supported by grants from the BASF Corporation, Hoffmann-LaRoche Inc., and the National Dairy Council.

Manuscript received 13 July 1988. Revision accepted 26 September 1988.

This article has been cited by other articles:

				S. Orita, M. Hirose, S. Takahashi, K. Imaida, N. Ito, K. Shudo, H. Ohigashi, A. Murakami, and T. Shirai Modifying Effects of 1'-Acetoxychavicol Acetate (ACA) and the Novel Synthetic Retinoids Re-80, Am-580 and Am-55P in a Two-Stage Carcinogenesis Model in Female Rats Toxicol Pathol, February 1, 2004; 32(2): 250 - 257. [Abstract] [PDF]