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Department of Nutrition, University of California, Davis, CA 95616
Development of folate deficiency (FD) was evaluated in weanling rats fed diets containing mixtures of free amino acids or of vitamin-free casein and gelatin as sources of dietary nitrogen. FD could be produced in 21 d with amino acid diets that promoted maximum growth rate, were completely devoid of folate and contained 1% succinylsulfathiazole. Growth retardation and blood dyscrasia associated with FD could not be demonstrated in rats fed diets containing casein and gelatin as nitrogen sources because the vitamin-free casein contained low but measurable levels of folate. The most effective protocol to produce experimental FD in rats is to feed a folate-free diet that otherwise supports maximum growth in young animals. Additional modifications such as use of methotrexate or amino acid-imbalanced or protein-deficient diets are unnecessary.
KEY WORDS: • folate deficiency • dietary proteins • amino acids
1 Supported by U.S. Public Health Service USPHS Grants No. AM-16726 and No. DK38637, U.S. Department of Agriculture, Grant No. USDA-CRGO-78-59-2063-0-1-065-1, USDA Regional Research Grant No. W143 and Hatch Grant No. 2850, California Agricultural Experiment Station.
2 Current address: Department of Physiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616.
3 To whom reprint requests should be addressed.
Manuscript received 6 August 1987. Revision accepted 29 April 1988.
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