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Hepatic Fatty Acid Synthesis and Triglyceride Secretion in Rats Fed Fructose- or Glucose-Based Diets Containing Corn Oil, Tallow or Marine Oil^1,2,

Department of Biochemistry, Memorial University of Newfoundland, St. Johns, Newfoundland A1B 3X9, Canada

The effects of three dietary fats, corn oil (CO), tallow (T) and marine oil (MO), on serum triglycerides, hepatic lipogenic enzyme activity and lipogenesis in vivo using ³H₂O were measured in fed and fasted rats that had been consuming diets in which the carbohydrate was either glucose or fructose. Hepatic triglyceride secretion was also measured in fasted rats fed the same diets. In both the fed and fasted state, hepatic enzyme activity and lipogenesis in vivo were greater in fructose-fed rats than in glucose-fed rats and less in both CO- and MO-fed rats than in T-fed rats. In rats fed glucose, serum triglycerides were lower in fasted rats fed MO than in fasted rats fed CO. In rats fed glucose or fructose, hepatic triglyceride secretion was lower in rats fed MO than in those fed CO or T.

KEY WORDS: • marine oil • 3 fatty acids • lipogenesis • triglyceride secretion

¹ Research supported by the Medical Research Council of Canada.

² Presented in part at the Annual Meeting of the Federation of American Societies for Experimental Biology, Washington, DC, April, 1987. [Herzberg, G. R. & Rogerson, M. (1987) Hepatic fatty acid synthesis in rats fed glucose or fructose based diets containing corn oil, tallow or fish oil. Fed. Proc. 46: 1005 (abs. 4014)].

Manuscript received 16 September 1987. Revision accepted 9 May 1988.