Journal of Nutrition Animal Diets/Enrichment Products...

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

Journal of Nutrition Vol. 118 No. 7 July 1988, pp. 895-900
Copyright © 1988 by American Society for Nutrition
This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tsao, C. S.
Right arrow Articles by Leung, P. Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tsao, C. S.
Right arrow Articles by Leung, P. Y.

Urinary Ascorbic Acid Levels Following the Withdrawal of Large Doses of Ascorbic Acid in Guinea Pigs1

Constance S. Tsao and Ping Y. Leung2

Linus Pauling Institute of Science and Medicine, Palo Alto, CA 94306

Male guinea pigs received sodium ascorbate solution [equivalent to 1 g ascorbic acid/(kg body weight·d)] by intraperitoneal injection for 4 wk. During the ascorbic acid treatment period, plasma and urinary ascorbic acid levels rose markedly. Three weeks after the ascorbic acid treatment was withdrawn, mean urinary ascorbic acid levels were significantly lower than their corresponding basal levels. At both 2 and 5 wk after withdrawal of ascorbic acid treatment, mean plasma ascorbic acid levels were below normal. The results indicate that these animals had experienced a transient withdrawal effect after administration of large doses of ascorbic acid that lasted about 1 wk. This, in turn, indicates that the rate of ascorbic acid turnover was probably increased during treatment, and this effect persisted even after the ascorbic acid was withdrawn. Examination of data from each individual experimental animal revealed that the pattern of urinary ascorbic acid excretion after the withdrawal of large doses of ascorbic acid varied from animal to animal. Among the twelve experimental guinea pigs, seven had abnormally low urinary ascorbic acid levels 2–4 wk after the withdrawal of the large doses of ascorbic acid.

KEY WORDS: • ascorbic acid • vitamin C • plasma • urine • systemic conditioning • rebound effect • guinea pigs

1 Supported in part by the Japan Shipbuilding Industry Foundation, Tokyo.

2 Irwin Stone Research Fellow, 1985–1986.

Manuscript received 14 January 1988. Revision accepted 4 March 1988.






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]