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The Paradoxical Response of Cardiac Glycogen to Oral Casein Hydrolysate in Rats

Section of Endocrinology, Metabolism and Nutrition, V. A. Medical Center, Minneapolis, MN 55417 ^* Department of Medicine and Department of Food Science and Nutrition, University of Minnesota, Minneapolis, MN 55417

In fasted rats, casein hydrolysate administration resulted in a marked increase in glycogen synthase I activity, no change in phosphorylase a and a marked decrease in glycogen concentration. This occurred with doses as small as 0.5 g/kg body weight. The major reason for an increase in synthase I appeared to be the reduced glycogen concentration, although insulin may play a role early in the time course. The decrease in glycogen in the absence of a change in phosphorylase a most likely is due to a decrease in an allosteric inhibitor. The nature of this inhibitor is unknown.

KEY WORDS: • protein • glycogen synthase • insulin • glycogenolysis • casein

¹ To whom reprint requests should be addressed.

² Supported by a grant from the Veterans Administration.

Manuscript received 30 November 1987. Revision accepted 1 March 1988.