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Role of Compensatory Gain in Eimeria acervulina—Induced Liver Copper Accumulation in Chicks¹

Department of Animal Science, Louisiana Agricultural Experiment Station, Louisiana State University Agricultural Center, Baton Rouge, LA 70803

An investigation was conducted to determine whether the Eimeria acervulina—induced increase in liver Cu accumulation in chicks is the result of compensatory gain that accompanies the recovery phase of infection. In experiment 1, chicks inoculated one time with 1 x 10⁶ sporulated E. acervulina oocysts had a faster rate of compensatory gain than chicks inoculated serially on three occasions with 4 x 10⁵ oocysts. However, liver Cu accumulation was nearly identical for the two infection regimes. In experiment 2, rate of compensatory gain and liver Cu accumulation was compared in 1) ad libitum—fed chicks; 2) restricted-fed chicks fed 40% of ad libitum intake followed by ad libitum intake; 3) coccidiosis-infected chicks, 1 x 10⁶ oocysts on d 2 of the experiment; and 4)–6) the same as 1)–3), respectively, but fed 500 mg Cu/kg diet. Restricted-fed chicks had a higher rate of compensatory gain than coccidiosis-infected chicks. Liver Cu accumulation was sixfold higher in coccidiosis-infected chicks than in restricted-fed chicks, however. In addition, liver Cu accumulation of the control (uninfected) chicks and the 40% restricted-fed chicks was identical. Thus compensatory gain during the recovery phase of coccidiosis is not responsible for the coccidiosis-induced increase in liver Cu accumulation.

KEY WORDS: • chicks • copper • coccidiosis • liver • compensatory gain

¹ Approved for publication by the director of the Louisiana Agricultural Experiment Station as manuscript no. 87-11-1280.

² To whom reprint requests should be addressed.

Manuscript received 9 February 1988. Revision accepted 17 February 1988.